O-304 Powder

What Is O-304

O-304 powder is an innovative compound that has recently garnered significant attention in the fields of energy metabolism and cardiovascular research. As an orally available pan-AMPK (5' AMP-activated protein kinase) activator, it possesses unique chemical and physiological advantages. In cellular studies, it inhibits PP2C-mediated dephosphorylation of pAMPK (phospho-AMPK), thereby maintaining and enhancing pAMPK levels without reducing ATP levels. This behavior mimics the protective effect of ADP, unlike classic AMPK activators, which rely on reduced ATP or increased AMP levels for activation. (PP2C dephosphorylation experiments have shown that it can stabilize p-T172 AMPK even in the presence of high ATP levels.) Notably, this mechanism renders it a more gentle and sustained AMPK activation tool, thereby preventing cellular errors or damage caused by energy depletion. MedChemExpress also describes it as a "first-in-class, orally available pan-AMPK activator that inhibits pAMPK dephosphorylation and has the potential to treat T2D and cardiovascular complications." Specifically, it is formulated as a highly pure, research-grade powder, making it easy for researchers to prepare stock solutions for cell-based or animal studies. Its stable chemical properties and safety profile make it a valuable tool in the mechanistic exploration of the AMPK pathway. O-304 is not an approved drug but is in preclinical to early clinical development for scientific research and mechanistic discovery. Due to its unique in vitro and in vivo regulation of AMPK, it is positioned not only for metabolic improvement but also for cardiovascular protection, exercise physiology, and aging research. It is considered a potential "exercise mimetic," mimicking the metabolic adaptations induced by exercise at the cellular and systemic levels. The above information is based on the conclusions of cell models and animal studies and is not intended for medical use and is provided for research reference only.

As one of the most popular products, powder has received many good comments and feedback from customers. What attracts customers mostly is the high quality. Additionally, Xi'an Sonwu offers a highly competitive price. For more information, please contact Xi'an Sonwu Biotech Co., Ltd.

Where To Buy O-304

Xi'an Sonwu Biotech Co., Ltd. has extensive experience in global trade and the healthcare industry. Insisting on faith-based and quality-first principles is Xi'an Sonwu's guiding principle. Xi'an Sonwu strictly controls product quality, which means that selection begins with the raw materials. Besides, Xi'an Sonwu handles every detail and minimizes costs to the maximum extent, allowing customers to obtain cost-effective products. Based on this, customers have provided a lot of positive feedback about the products. So look for Xi'an Sonwu Biotech Co., Ltd. when buying it.

Xi'an Sonwu ensures the product's quality so that samples can be supplied. Here is the quantity.

The Action of O-304

The mechanisms of action demonstrated in cell and animal models for O-304 are profound and comprehensive. First, in vivo studies have demonstrated that it significantly improves glucose homeostasis and -cell function. For example, in diet-induced obese (DIO) mice, oral administration of it significantly reduced fasting blood glucose and insulin levels, and significantly improved the HOMA-IR (insulin resistance index), demonstrating a significant improvement in insulin sensitivity. This effect was even more pronounced when administered in combination with metformin. Furthermore, in a Phase IIa clinical trial in patients with T2D, it not only improved glucose homeostasis but also significantly enhanced peripheral microcirculatory function, including skin microvascular perfusion, which is a common mechanism leading to the severe consequences of T2D. Furthermore, it has profound effects on cardiovascular and exercise endurance in aged mice. Studies have found that aged mice fed it showed significantly improved cardiac function indicators, such as cardiac output, ejection fraction, and infarct volume, compared to the control group. This improvement was also accompanied by a reduction in insulin resistance and hyperinsulinemia, reflecting its potential to promote cardiac metabolism, energy utilization, and overall metabolic homeostasis. In aging models, it also demonstrated significant improvements in skeletal muscle glucose uptake, as assessed by PET, accompanied by increases in p-ACC (ACC Ser79) levels and decreases in TXNIP expression, suggesting a potent role in promoting metabolic adaptation and enhancing muscle energy utilization. In cellular experiments, O-304 has also been observed to promote autophagy and alleviate mitochondrial dysfunction. For example, in a model of oxidative stress, it significantly increased the formation of LC3B-positive autophagosomes, promoting autophagic flux, and restoring the expression of key factors involved in mitochondrial biogenesis (such as PGC-1 and TFAM), reducing ROS production, and restoring mitochondrial ultrastructure, suggesting a protective role in maintaining cellular quality control and energy metabolism. Overall, it's mechanism of action spans the molecular level (AMPK activation and prevention of dephosphorylation), the cellular level (maintaining metabolic homeostasis, protecting mitochondria, and promoting autophagy), and the in vivo system (improving insulin sensitivity, cardiovascular function, exercise endurance, and aging phenotypes), presenting a comprehensive research pathway from fundamental mechanisms to overall physiological improvements. This is precisely why researchers are paying close attention to its "exercise-mimicking" potential and its dual metabolic and cardiovascular protective effects.

O-304 powder has a wide range of applications, encompassing metabolic disease research, exercise physiology, cardiovascular protection, exploration of aging mechanisms, and specific pathological model studies. Firstly, in metabolic disease research, it has been widely used in mouse models (such as diet-induced obese mice) as a tool to study the effects of AMPK activation on pancreatic -cell protection, glucose metabolism regulation, and insulin resistance. By significantly lowering blood glucose and insulin levels, increasing skeletal muscle glucose uptake, and improving HOMA-IR, O-304 provides high-quality experimental material for studying the pathogenesis and intervention strategies of metabolic syndrome and type 2 diabetes. In cardiovascular and exercise adaptation studies, it has demonstrated significant benefits. In aging mouse models, it not only improves cardiac pumping function but also enhances exercise endurance and muscle glucose utilization efficiency, making it an ideal candidate for exploring the molecular mechanisms of "exercise-mimicking effects," particularly in settings where regular exercise intervention is not possible. Furthermore, O-304's enhanced microcirculation makes it uniquely valuable in the study of microvascular perfusion and circulatory disorders, making it particularly suitable for investigating blood flow issues associated with diabetic complications. From a cellular mechanistic perspective, O-304 has been widely used in experiments investigating the autophagy pathway, mitochondrial function, and cell quality control. In stress-induced cell models, it has been shown to promote autophagy, alleviate mitochondrial structural abnormalities and oxidative damage, and restore the expression of key mitochondrial factors. This opens new avenues for exploring the connection between aging, physiological stress, and metabolic homeostasis. Furthermore, its high-purity, soluble powder form, stability, and oral availability make it a preferred choice for research institutions and drug discovery agencies, both for basic biological mechanism research and early-stage drug development. In terms of study design, it can be used in controlled experiments with traditional AMPK activators (such as AICAR and metformin), enabling researchers to compare mechanisms, conduct dose-escalation studies, and analyze multi-pathway interactions. O-304 offers a research tool with pharmacological activity, chemical stability, and mechanistic clarity, enhancing the field of metabolism and aging research by making research designs more convincing and systematic.

Xi'an Sonwu production factory is well-equipped, clean, and tidy, with sufficient stock. Under the leadership of the company, researchers continue to develop new products. The laboratory's testing environment features advanced testing equipment and professional testers, all of whom adhere to a strict approach to providing valuable data for the products and ensuring customers receive a quality experience.

In addition to guaranteeing product quality, the other most vital thing is that clients can receive the goods smoothly. Therefore, Xi'an Sonwu supplies various couriers according to different needs.

Xi'an Sonwu has been engaged in import and export for over 10 years, accumulating rich experience in the industry.

Xi'an Sonwu has 10 years of experience in product development, production and sales.

Xi'an Sonwu has a professional team with a clear division of labor.

Xi'an Sonwu has professional laboratories and equipment to ensure the production of high-quality products.

Products are tested by third parties.

Xi'an Sonwu provides OEM service.

Xi'an Sonwu provides 7*24 customer service.

O-304 powder, please do not hesitate to contact Xi'an Sonwu.

E-mail: sales@sonwu.com

Populāri tagi: o-304 powder, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, raw, supply, for sale